Abstract Background Despite of the frequently reported Dnmt3a abormality in classical myeloproliferative neoplasms (cMPNs) patients. few research explores how the Dnmt3a is regulated by Jak2V617F mutation. In this study. we have investigated how the Dnmt3a is regulated by Jak2V617F mutation and its effects on downstream signaling pathways in cMPNs. https://parisnaturalfoodes.shop/product-category/one-step-cleanser/