Summary: Recognition of N-linked glycan at residue N276 (glycan276) at the periphery of the CD4-binding site (CD4bs) on the HIV-envelope trimer is a formidable challenge for many CD4bs-directed antibodies. To understand how this glycan can be recognized. here we isolate two lineages of glycan276-dependent CD4bs antibodies. Antibody CH540-VRC40. https://fitnessgravesyardes.shop/product-category/tramsformer-t2/