Aim. To examine the course of chronic cardiac failure (CCF). morphofunctional parameters of the heart in correlation with activity of cytokine system; to evaluate effectiveness. tolerance and safety of combined CCF treatment including a cardioselective fi-adrenoblocker bisoprolol in patients with CCF FC I-IV having a high plasm level of tumor necrosis factor a (TNF-a). https://crowssportes.shop/product-category/ringette-ring/